Triptorelin (Décapeptyl®, Diphereline®): indications and use

Triptorelin is an analogue of the natural gonadotropin-releasing hormone (GnRH), widely used in the treatment of infertility in women, as well as in diseases such as endometriosis and uterine fibroids. The main effect of the drug is to regulate the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by the pituitary gland.

The drug works by suppressing the natural secretion of gonadotropins, initially causing a short-term increase in LH and FSH levels, followed by their decrease by reducing the pituitary's sensitivity to the gonadotropin-releasing hormone. This allows for the control of ovulation and prevents premature hormonal surges.

Use of Triptorelin in an IVF protocol

Triptorelin is available in powder form for intramuscular or subcutaneous injection depending on the dosage and is used as part of in vitro fertilization (IVF) for the controlled stimulation of ovulation.

Main objective of use in IVF

The main objective of the drug in the IVF protocol is to suppress LH spikes and prevent premature ovulation, which improves egg quality. Premature LH release can lead to accelerated maturation and poorer quality of oocytes, reducing the chances of fertilization. Maintaining stable LH levels promotes regular maturation of oocytes, thereby increasing the chances of successful conception.

When and how to use Triptorelin in IVF?

The use of this drug helps avoid premature luteinization of the follicles, a process during which, under the influence of LH, the dominant follicle transforms into a corpus luteum without the egg being released, making conception impossible.

Uses in IVF protocols:

1. Short protocol - small doses of the drug are administered starting from the first day of the menstrual cycle. The treatment may include 10 to 12 doses.
2. Long protocol - the drug is administered starting from the 21st day of the menstrual cycle. Stimulation is stopped when the follicles reach a size of 17-19 mm.
3. After embryo transfer - the drug may be administered from the 2nd or 3rd day and continued for several weeks, depending on the individual protocol. It helps to block ovarian function and increases the likelihood of successful embryo implantation.

Possible side effects:

• Headaches.
• Hot flashes.
• Mood swings.
• Minor changes in the menstrual cycle.

Triptorelin in gynecological diseases

The drug is also used in the treatment of various gynecological pathologies. The duration of treatment depends on the form of the disease and the patient's age.

• Treatment may last from 3 to 6 months.
• Recovery of ovarian function and ovulation usually occurs 58 days after the end of injections.
• The menstrual cycle is generally restored on the 70th day after the end of treatment.

Triptorelin for endometriosis

This medication prevents the production of gonadotropic hormones, which stimulate the ovaries and consequently cause a decrease in estrogen levels (hypo-estrogenism). This results in the suppression of menstruation (amenorrhea) and simultaneously the disappearance of bleeding at the sites of endometriosis lesions. By preventing the proliferation of lesions, Triptorelin contributes to the reduction of pathological foci, promoting remission.

Main principles of treatment:

1. Treatment is conducted over a period of 3 months.
2. Injections are given every 28 days.
3. At the end of treatment, a long IVF protocol is often recommended, which significantly increases the chances of successful pregnancy in women with endometriosis.

More information

Further information about the use of Triptorelin in IVF protocols can be obtained from a specialist doctor at the Natuvitro clinic. It is also recommended to read scientific studies and official medical recommendations, such as publications from the World Health Organization (WHO) and the European Society of Human Reproduction and Embryology (ESHRE).