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IVF In Vitro Fertilization with PGT

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What is a PGT?

Preimplantation Genetic Testing (PGT) has represented a significant advance in understanding the causes of infertility - and of course in implementing some of its solutions. These tests can be of different types, depending on what we are looking for, with the most common being PGT-A (or PGS), PGT-M, or PGT-SR. Pre-implantation Genetic Testing, commonly known as PGT, is carried out within the framework of In Vitro Fertilization, and consists of performing a minimally invasive analysis of each embryo before its implantation in the uterus. The objective of these tests is to identify possible genetic disorders that currently prevent or make pregnancy difficult, or that could cause the baby to develop a serious illness.

What is PGT useful for?

The objective of these tests is to identify possible genetic disorders that may currently prevent or impede pregnancy, or that may cause the baby to develop a serious illness.

It allows to reduce risks due to genetic causes: The analysis of the embryo with PGT allows us to drastically reduce the risk of transmission of genetic malformations with serious consequences for the future baby throughout their life.
Increase IVF success rates: PGT offers a remarkable improvement in IVF success rates as it allows us to detect in advance embryos affected by genetic abnormalities that would hinder their development, their implantation in the uterus or increase the chances of a spontaneous miscarriage.

A visit to the clinic will bring you closer to your dream of having a child. Schedule a consultation with our doctor!

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What are the differences between the different types of PGT: PGTA, PGT-M or PGTSR?

PGT-A or PGS

PGT-A

Preimplantation genetic testing for aneuploidy

With PGS or PGTA, we seek to know which embryos have a higher chance of becoming a healthy baby. During the course of In Vitro Fertilization, once an egg is fertilized and has become a blastocyst, our biologists obtain a small sample of the trophoblast, which is the group of outer cells that do not form part of the actual embryo, as they are destined to become the future placenta. While the embryo remains in the safe environment of the incubator, a specialized laboratory analyzes the 23 pairs of chromosomes using massive sequencing. We are checking for the presence of aneuploidies, which means additional chromosomes (trisomy) or missing chromosomes (monosomy). PGS or PGT-A is indicated in cases of advanced age, repeated miscarriages, implantation failures, or in cases of male factor with a possible genetic cause.

PGT-M

Preimplantation genetic testing for monogenic disorders

What we are looking for with this test is to delve into the possible mutations in the DNA that makes up each of the chromosomes. Genetic failures or anomalies can lead to serious diseases such as Beta thalassemia, cystic fibrosis, muscular dystrophy, hemophilia, among others.

PGT-M is indicated when we have family history that recommends its realization, and consists of:

A first evaluation by a doctor
Taking saliva or blood samples.
Biopsy of the trophoectoderm of each embryo.

Once the genetic analysis is performed by a specialized laboratory, it will indicate which embryos are suitable for transfer, thus minimizing the risk of transmitting a serious disease to the future baby.

PGT-SR

Preimplantation genetic testing for structural rearrangements

There are other types of DNA mutations called structural rearrangements. In these cases, we observe that a region of the chromosome itself is affected, either by a translocation, an inversion, a duplication, or a microdeletion. These rearrangements occur in 5% of individuals diagnosed with infertility. In a translocation, a fraction of the chromosome joins another different chromosome. It is called reciprocal when the segments are exchanged. In the case of duplication, a part of the chromosome has been copied during cell meiosis. A microdeletion is the opposite: a part of the chromosome is deleted. An inversion means that the chromosomal region exists but points in the opposite direction. These rearrangements can occur in both men and women, and of course in both at the same time, and they can lead to difficulties in embryonic development, implantation failures, and spontaneous abortions. The future baby could also develop numerous syndromes such as Down syndrome, Edwards syndrome, Patau syndrome, or have their intellectual or physical abilities affected. PGTSR is indicated when there are family history recommendations for its performance, and it consists of: - An initial evaluation by a doctor of both members of the couple - Collection of saliva or blood samples from both - Biopsy of the trophoblast of each embryo

Phases of the double donation or IVF process with donors

1Consultation and analytics/tests

2Stimulation and egg retrieval
(12-15 days)

3ICSI and embryo cultivation
(5-6 days)

4Biopsy and genetic testing
(10-12 days)

5Endometrial preparation and embryo transfer

IVF+PGT
Cycle

Success rates

At NatuVitro, the chances of getting pregnant increase the more attempts you make. With your own eggs, on the first attempt, you have a 66.5% chance of achieving it (using all the embryos obtained in that cycle, but in different transfers), reaching 91.8% on the third attempt.

Age is a very important variable that affects treatment success rates. These rates are very high because we personalise hormone stimulation, adapting it to the needs of each patient and because we have advanced in vitro fertilisation laboratories where the embryos are developed and selected under the best possible conditions.

< 30

84%

30 - 34

81%

35 - 39

68%

40 - 44

59%

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Different options

PGT prices

IVF with PGT-A

Preimplantation Aneuploidy Genetic Testing
Personalized counseling by a specialized gynecologist and coordinator in Assisted Reproduction
IVF-Witness security system that guarantees traceability of samples throughout the treatment process
Cycle monitoring stimulated by your Natuvitro specialist
All ultrasounds and hormonal analyses performed at NatuVitro clinic**
Oocyte retrieval in the operating room with sedation anesthesia.
Preparation of semen sample
ICSI or conventional fertilization of mature oocytes obtained
Culture in state-of-the-art time-lapse incubator for embryo or embryos until reaching the blastocyst stage
Biopsy and genetic diagnosis using NGS (Next Generation Sequencing) technology of the first blastocyst
1 transfer
Pregnancy tests performed at NatuVitro clinic**
Pregnancy monitoring up to the 8th week at NatuVitro clinic**

7.195 €

IVF with PGT-SR

Preimplantation genetic testing for structural rearrangements
Personalized counseling by a gynecologist and a specialized coordinator in Assisted Reproduction
IVF-Witness security system that guarantees the traceability of samples throughout the treatment process
Cycle monitoring stimulated by your Natuvitro specialist
All ultrasounds and hormonal analyzes performed at NatuVitro clinic**
Egg retrieval in the operating room with sedation anesthesia.
Preparation of semen sample
ICSI or conventional fertilization of mature eggs obtained
Culture in state-of-the-art time-lapse incubator for embryo or embryos until reaching the blastocyst stage
Biopsy and genetic diagnosis using NGS (Next Generation Sequencing) technology of the first blastocyst
1 transfer
Pregnancy tests performed at NatuVitro clinic**
Pregnancy monitoring until the 8th week at NatuVitro clinic**

7.195 €

IVF with PGT-M

Preimplantation genetic testing for monogenic disorders
Early genetic diagnosis performed on the embryo before its transfer to the uterus, as part of IVF treatment
Selection of embryos that do not have the disease to be transferred to the uterus
Personalized counseling by a specialized gynecologist and coordinator in Assisted Reproduction
IVF-Witness security system that guarantees traceability of samples throughout the treatment process
Cycle monitoring stimulated by your Natuvitro specialist
All ultrasounds and hormonal analyses performed at the NatuVitro clinic**
Oocyte retrieval in the operating room with sedation anesthesia.
Preparation of the semen sample
ICSI or conventional fertilization of mature oocytes obtained
Culture in state-of-the-art time-lapse incubator for the embryo or embryos until reaching the blastocyst stage
Biopsy and genetic diagnosis using NGS (Next Generation Sequencing) technology of the first blastocyst
1 transfer
Pregnancy tests performed at the NatuVitro clinic**
Pregnancy follow-up until the 8th week at the NatuVitro clinic**

Personalized price

Meet the team

You can make an appointment with any doctor on a date that suits you.

At NatuVitro, you will be followed by the same doctor from the beginning to the end, supervising your entire treatment from your first visit, thus offering continuity of individualized care: our patients appreciate this great difference with most of the assisted reproduction centers in Spain.