Successfully overcoming five years of infertility: detailed analysis of a clinical FIV case

Prolonged infertility is a major challenge both for couples and for specialized reproductive medicine doctors. The situation becomes more complicated when the patient presents not just one, but several gynecological pathologies. However, the possibilities offered by modern medicine and in vitro fertilization (IVF) programs enable achieving the much-awaited pregnancy, even in cases that, just a decade ago, were considered extremely complex. In this article, we will analyze in detail a successful clinical case from the practice of the natuvitro clinic.

History and Medical Background

The patient sought our help with a diagnosis of "primary infertility" that had been ongoing for 5 years. During this period, the couple underwent numerous tests and treatment attempts that did not lead to pregnancy.

The patient's medical records indicated the following aggravating factors:

• Surgical intervention: a laparoscopic operation had been performed previously to remove an ovarian cyst, which always requires careful attention to ovarian reserve.
• Adenomyosis: presence of endometriosis foci within the muscular layer of the uterus, which can complicate the implantation process.
• Chronic endometritis: inflammatory process of the uterine lining, which required mandatory pre-treatment before entering the protocol.
• Failure of intrauterine insemination: in 2024, an intrauterine insemination attempt with the husband's sperm was carried out at a third-party medical facility but did not result in pregnancy.

This combination of diagnoses significantly reduced the chances of natural conception and necessitated the use of advanced assisted reproductive technologies.

Choice of Therapeutic Strategy at the natuvitro Clinic

In November 2025, the couple began treatment within an IVF program. Considering the medical history, the doctors chose a "cycle segmentation" strategy. The main idea was to perform controlled ovarian stimulation followed by mandatory cryopreservation of all obtained embryos.

This was justified for two reasons:

1. To avoid the risk of ovarian hyperstimulation syndrome in case a large number of oocytes are retrieved.
2. To give the body time to recover and prepare the endometrium for transfer under more natural conditions, without hormonal overload.

Program Progress and Embryological Phase Results

The stimulation phase proceeded successfully. Following the retrieval, the doctors managed to collect 20 oocytes, demonstrating a good ovarian response to medication.

The subsequent laboratory steps yielded excellent results:

• Fertilization and culture were conducted up to the blastocyst stage (day 5 of development).
• On day 5, 16 high-quality blastocysts were obtained.
• All embryos were successfully vitrified (frozen) for future use.

Such a number of high-quality embryos offers the couple not only great chances of success for the current cycle but also the possibility to plan the birth of a second child and subsequent ones in the future.

Embryo Transfer and Pregnancy Confirmation

The preparation for transfer was meticulous, given the previous occurrence of endometritis. On January 19, 2026, two embryos were transferred into the uterine cavity. At the time of the procedure, the endometrial condition was considered ideal: its thickness was 14 mm, which is an optimal indicator for successful implantation.

The results were quick to follow:

• Two weeks later (14 days after transfer), the blood hCG test showed a value of 1,727 mU/L, clearly indicating the start of an ongoing pregnancy.
• On February 13, 2026, the patient underwent her first ultrasound, during which the doctor confirmed the presence of a fertilized ovum and its normal development.

Analysis of Success and Clinical Significance

This case clearly illustrates that diagnoses such as "adenomyosis" and "chronic endometritis" are not definitive verdicts when an appropriate medical approach is adopted. The success achieved at the natuvitro clinic was made possible thanks to:

1. A personalized stimulation protocol.
2. The high quality of the embryology team's work.
3. Gradual preparation of the uterus to receive the embryos.
4. A precise selection of the "implantation window".

For couples facing similar problems, this case provides an important reminder: modern assisted reproductive technology can resolve the most complex issues, provided that treatment is based on evidence-based principles and a comprehensive approach.

Frequently Asked Questions (FAQ)

1. Why, even though there were 16 embryos, only two were transferred?

Transferring one or two embryos is a safety standard. It minimizes the risks of a multiple pregnancy, which can be difficult for the mother's body to support. The remaining 14 embryos are preserved in the cryobank.

2. How does adenomyosis affect IVF?

Adenomyosis can alter the structure of the uterus and reduce endometrial receptivity. However, using cryopreservation protocols combined with specific medication preparation allows overcoming these obstacles and achieving implantation.

3. Is an endometrial thickness of 14 mm normal?

Yes, it is an excellent indicator for the transfer phase. The optimal range is between 8 and 14 mm. A value of 14 mm indicates that the lining is well prepared for fertilized egg implantation.

4. Should chronic endometritis be treated before IVF?

Absolutely. Untreated endometritis is one of the main causes of implantation failure. As shown in this clinical case, preconditioning of the endometrium is key to success.

5. Why was IUI ineffective in 2024, while IVF was successful in 2026?

Intrauterine insemination (IUI) has a much lower success rate (around 10-15%) and does not address issues related to oocyte quality or endometrial pathologies, whereas IVF allows full control over the fertilization process and embryo development.