Obstructive sleep apnea syndrome as a risk factor for male infertility

Impact of Sleep Disorders on Male Fertility

A study published in JAMA Network Open in 2024 confirmed that sleep disorders, particularly obstructive sleep apnea (OSA), can significantly increase the risk of infertility in men. OSA is characterized by periodic pauses in breathing during sleep, leading to a lack of oxygen, chronic fatigue, and dysfunctions in the endocrine system.

Research on the Relationship Between OSA and Infertility

A team of researchers led by Yi-Han Zhuang from the Department of Surgery at Tri-Service Medical Center (Neihu, Taipei, Taiwan) analyzed data from Taiwan's national health insurance database. The primary objective of the study was to examine the association between sleep disorders and conception issues in men.

The study involved 4607 infertile men and 19428 men under medical supervision. The sample included patients whose infertility diagnosis had been confirmed, as well as men who had at least three outpatient consultations and one hospitalization episode. The groups were compared based on criteria such as age, consultation date, causes of infertility, and other parameters.

Study Results

The data analysis showed that obstructive sleep apnea is a significant risk factor for male sterility. Logistic regression analysis confirmed that men suffering from diagnosed OSA were significantly more likely to develop infertility than those who did not suffer from it.

The researchers note that chronic hypoxia (lack of oxygen due to respiratory pauses during sleep) can lead to:

• hormonal imbalance and decreased testosterone levels;
• deterioration of sperm quality and motility;
• increased levels of oxidative stress, which negatively affects the spermatogenesis process;
• general disruption of metabolic processes, which negatively impacts reproductive health.

Importance of Diagnosing and Treating OSA

The results of this study highlight the need for timely diagnosis and treatment of obstructive sleep apnea in men, especially those who have difficulties conceiving. Including the diagnosis of sleep disorders in the examination program for infertile couples will help identify other factors affecting fertility and correct them in time.

Specialists at the "Natuvitro" clinic recommend that men considering parenthood pay attention to possible symptoms of hypersomnia syndrome, including:

• loud snoring and periodic pauses in breathing during sleep;
• chronic fatigue and daytime drowsiness;
• concentration and memory troubles;
• decreased libido and potency issues.

Early diagnosis and appropriate treatment of sleep apnea can help improve overall health, normalize testosterone levels, and increase the chances of conception. The Natuvitro clinic offers comprehensive diagnosis and treatment of the causes of male infertility, including sleep tests and correction of sleep-related respiratory disorders. You can schedule an appointment for a consultation in the "Contacts" section of the clinic's website.