Infertility of unknown origin

Idiopathic infertility is a decrease in the ability to conceive, the cause of which has not been determined by modern diagnostic methods. The frequency of the diagnosis of idiopathic infertility is decreasing as the diagnostic methods used in reproductive medicine are constantly improving, including modern technologies such as genetic testing, laparoscopy, hysteroscopy, and advanced hormonal profiling tests.

Causes of fertility disorders of uncertain origin

The main causes of infertility with unclear genesis are as follows:

1. Gender - Indeed, in 1/3 of men, the cause of infertility cannot be established, as confirmed by data from studies conducted in a number of clinics.
2. Age - the likelihood of infertility increases with age, particularly in women after 30. According to a study, women over 35 have half the chances of conceiving a child compared to younger women.
3. Lifestyle - bad habits (smoking, alcohol), unfavorable working conditions, and chronic stress significantly reduce fertility. According to the World Health Organization, up to 25% of infertility cases are related to lifestyle.

Diagnosis of the pathology

The diagnosis of idiopathic infertility at the "NatuVitro" medical center is made after conducting a number of diagnostic tests:

• tests to determine the activity of sex hormones;
• Shuvarsky test;
• diagnosis of reproductive organ infections;
• pelvic organ ultrasound to detect organic disorders;
• in women, examination of the patency of the fallopian tubes;
• in men - study of the ejaculate and MAR test.

To exclude the immunological factor of fertility disorders, it is advisable to conduct research on:

• the level of anti-sperm antibodies in the ejaculate and cervical mucus - high levels of antibodies may prevent sperm penetration and reduce the likelihood of conception;
• HLA - compatibility of the couple - incompatibility may provoke an immune reaction that prevents embryo implantation;
• the presence of genetic anomalies - eliminating genetic anomalies can help avoid immune reactions that may prevent successful conception.

If the results of the aforementioned studies are negative, it can be stated that this is idiopathic infertility.

In addition to the aforementioned diagnostic methods, it is recommended for partners to lead a healthy lifestyle, eat properly and rationally, avoid stress, and give up bad habits. Regarding the psychological nature of infertility, consulting a psychotherapist is advised.

Therapeutic methods

The "NatuVitro" medical center uses assisted reproductive methods for the treatment of idiopathic infertility:

1. Intrauterine insemination - introduction of sperm directly into the uterine cavity using a catheter. This procedure is recommended for women aged 35 years at most, whose infertility has been diagnosed for less than three years. If pregnancy does not occur after three attempts of intrauterine insemination, it is recommended that the patient move on to other treatment methods, such as IVF.
2. Stimulation - use of medications that provoke the maturation of several follicles at once, increasing the chances of fertilization. After the procedure, fertilization may occur naturally, by intrauterine insemination, or by in vitro fertilization (IVF).
3. In vitro fertilization (IVF) - if the previous methods have not succeeded, in vitro fertilization may help a couple conceive.

IVF is one of the most effective treatments for infertility, and its results are constantly improving due to advancements in technology and medical approaches such as preimplantation genetic diagnosis (PGD), embryo cryopreservation through vitrification, and the use of assisted hatching.